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A recent study from the group of Prof. Miron of the College of Dental Medicine, at the Nova Southeastern University, FL (USA), confirmed the following properties of maxresorb®: Ideal rough surface Great potential to absorb/release growth factors, such as rhBMP2 and rhBMP9 Significant stimulation of osteoblast differentiation These are all crucial properties for bony regeneration! Published in: Clin Oral Investig. 2016 Oct 22. [Epub ahead of print]. Recombinant human bone morphogenetic protein (rhBMP)9 induces osteoblast differentiation when combined with demineralized freeze-dried bone allografts (DFDBAs) or biphasic calcium phosphate (BCP). Fujioka-Kobayashi M, Schaller B, Zhang Y, Kandalam U, Hernandez M, Miron RJ. More information on maxresorb® at https://botiss-dental.com/products/maxresorb/ The study is available here: https://www.ncbi.nlm.nih.gov/pubmed/27771827...

A new study about a novel liquid carrier system for enamel matrix proteins in combination with collacone® has recently been published: Miron RJ, Fujioka-Kobayashi M, Zhang Y, Sculean A, Pippenger B, Shirakata Y, Kandalam U, Hernandez M. Osteogain® loaded onto an absorbable collagen sponge induces attachment and osteoblast differentiation of ST2 cells in vitro. Clin Oral Investig. 2016 Dec 1. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/27909893 Objectives: The goal of this study was to determine the potential of Osteogain®, a liquid carrier for enamel matrix derivative, in combination with collacone® as a regenerative therapy for extraction socket management. The collacone® sponge was loaded with Osteogain® and the protein resorption and release as well as osteoblast binding and differentiation were investigated. Results: The proteins in Osteogain® were efficiently absorbed by collacone® and gradually released after a 10-day time period. Osteogain® induced a 50% increase in cell adhesion to collacone® and significantly stimulated cell differentiation as evidenced by the...

[vc_row row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern" css_animation=""][vc_column][vc_column_text] Guided tissue and guided bone regeneration (GTR, GBR) are well-established techniques in dentistry to augment lost tissue around teeth and dental implants respectively (Nyman et al. 1980, Karing et al. 1980, Nyman et al. 1982, Dahlin et al. 1988). The basic principle of these methods is the placement of a barrier membrane between the soft tissue and residual bone in order to prevent the fast-proliferating epithelial cells from populating the bony defect and to provide space and time for the migration of slow-dividing osteogenic or periodontal ligament cells into the defect area.   Dr. Sascha Böhm and Dr. Sandra Wrobel, Scientific Product Managers at botiss biomaterials, Berlin/Germany. In the course of the evolution of GTR and GBR techniques, different types of membranes have been developed. Today, commercially available barrier membranes for GTR or GBR procedures can be divided into either non-resorbable or resorbable membranes. Non-resorbable membranes,...

by Zirk and colleagues: Prevention of post-operative bleeding in hemostatic compromised patients using native porcine collagen fleeces-retrospective study of a consecutive case series, evaluated the application of collagen fleeces following surgical tooth extraction in patients receiving anticoagulant drugs. Conclusion: The study demonstrated that adequate local hemostyptic methods such as the application of collagen fleeces in combination with atraumatic surgeries (tooth extractions) showed beneficial outcomes regarding the preventing of heavy bleeding in hemostatic compromised patients, regardless of their anticoagulant therapy.> DETAILS...

by Fienitz and colleagues: Histological and radiological evaluation of sintered and non-sintered deproteinized bovine bone substitute materials in sinus augmentation procedures. A prospective, randomized-controlled, clinical multicenter study, analyzed the effect of cerabone®* in comparison to Bio-Oss in augmentation sites. Conclusion: No significant differences between the groups could be detected with regard to residual bone height, new bone formation and residual bone substitute. Therefore, both bone substitute materials allow predictable new bone formation in sinus augmentation procedures. >DETAILS. *Study refers to Alpha Bio's Graft®, which is a former private label of cerabone®....