{"id":11893,"date":"2019-10-12T14:33:56","date_gmt":"2019-10-12T12:33:56","guid":{"rendered":"https:\/\/botiss.com\/product\/prospective-cohort-study-with-maxgraft-in-comparison-to-autologous-graft-on-cell-free-dna-cfdna-release-into-patients-blood-circulation-2\/"},"modified":"2024-07-24T10:00:07","modified_gmt":"2024-07-24T08:00:07","slug":"prospective-cohort-study-with-maxgraft-in-comparison-to-autologous-graft-on-cell-free-dna-cfdna-release-into-patients-blood-circulation-2","status":"publish","type":"product","link":"https:\/\/botiss.com\/de\/produkt\/prospective-cohort-study-with-maxgraft-in-comparison-to-autologous-graft-on-cell-free-dna-cfdna-release-into-patients-blood-circulation-2\/","title":{"rendered":"Prospective cohort study with maxgraft\u00ae in comparison to autologous graft on cell-free DNA (cfDNA) release into patient\u00b4s blood circulation"},"content":{"rendered":"<p>&nbsp;<\/p>\n<h4><span style=\"color: #000000;\">Characterization of circulating DNA in plasma of patients after allogeneic bone grafting<br \/>\n<\/span><span style=\"color: #00ccff;\">\u00d6. Solakoglu, B. Steinbach, W. G\u00f6tz, G. Heydecke, K. Pantel, H. Schwarzenbach, <em>Clin. <\/em><em>Oral. Invest.<\/em> <strong>2019<\/strong>. DOI: 10.1007\/s00784-019-02867-3<\/span><\/h4>\n<p>&nbsp;<\/p>\n<h4><a href=\"https:\/\/www.springermedizin.de\/characterization-of-circulating-dna-in-plasma-of-patients-after-\/16522676\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000;\">https:\/\/www.springermedizin.de\/characterization-of-circulating-dna-in-plasma-of-patients-after-\/16522676<\/span><\/a><\/h4>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\"><strong>Within this study, the amount of foreign cfDNA before and after grafting with maxgraft\u00ae as well as possible foreign Y-DNA transmission was examined in comparison with autografts.<\/strong><\/span><\/p>\n<p><span style=\"color: #00ccff;\"><strong>Objectives<\/strong><\/span><br \/>\nCell-free DNA (cfDNA) harboring mutations has been found in patients with diseases. Experimental studies have shown that cfDNA can be transmitted, leading to transformations in the host. In the present study, it evaluated whether bone allograft material contains cfDNA and whether this foreign cfDNA can be released into the patient\u2019s blood circulation.<\/p>\n<p><span style=\"color: #00ccff;\"><strong>Materials and methods<\/strong><\/span><br \/>\nPlasma samples were collected preoperatively and postoperatively on the same day, at 5 weeks, and 4 months from 25 women who received bone allograft material (test group) from male donors and from 10 women who were treated with autologous graft (control group, only pre- and postoperative samples were collected). DNA was quantified and characterized in bone material and plasma samples by quantitative PCR with primers specific for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Y chromosome and gel electrophoresis. DNA in bone material was digested by different concentrations of DNase I.<\/p>\n<p><span style=\"color: #00ccff;\"><strong>Results<\/strong><\/span><br \/>\nThe authors detected between 1 and 1.8 \u03bcg cfDNA fragments at a length around 601 base pairs (bp) and smaller in each 100 mg allograft. Treatment of the allograft with DNase I completely degraded the longer but not the shorter DNA 90-bp fragments. YDNA was not detected in the patients\u2019 bloodstream at any time during the treatment and follow-up, but elevated levels of circulating cfDNA could be measured immediately postoperatively.<\/p>\n<p><strong><span style=\"color: #00ccff;\">Conclusions<\/span><br \/>\n<\/strong>The authors\u2019 results suggest that a transmission of DNA from allografts used for alveolar ridge reconstruction in humans is unlikely. The observed increase in circulating cfDNA in allograft and autograft patients immediately postoperatively may be elicited by the surgical procedure.<\/p>\n<p><strong><span style=\"color: #00ccff;\">Clinical relevance<\/span><br \/>\n<\/strong>The results support the safety of allograft materials. The results suggest that human allograft materials seem not to release DNA into the blood since it was not measured Y-DNA with the applied technique.<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #00ccff;\">\u00d6nder Solakoglu<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Characterization of circulating DNA in plasma of patients after allogeneic bone grafting \u00d6. Solakoglu, B. Steinbach, W. G\u00f6tz, G. Heydecke, K. Pantel, H. Schwarzenbach, Clin. Oral. Invest. 2019. DOI:  &#8230;<\/p>\n","protected":false},"featured_media":11678,"template":"","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"product_brand":[],"product_cat":[1714,1756],"product_tag":[1974,1975],"class_list":["post-11893","product","type-product","status-publish","has-post-thumbnail","product_cat-ciencia","product_cat-estudios","product_tag-granulos-maxgraft","product_tag-reconstruccion-de-crestas","first","instock","product-type-simple"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.7 (Yoast SEO v27.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Prospective cohort study with maxgraft\u00ae in comparison to autologous graft on cell-free DNA (cfDNA) release into patient\u00b4s blood circulation - botiss biomaterials GmbH<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/botiss.com\/de\/produkt\/prospective-cohort-study-with-maxgraft-in-comparison-to-autologous-graft-on-cell-free-dna-cfdna-release-into-patients-blood-circulation-2\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prospective cohort study with maxgraft\u00ae in comparison to autologous graft on cell-free DNA (cfDNA) release into patient\u00b4s blood circulation\" \/>\n<meta property=\"og:description\" content=\"&nbsp; Characterization of circulating DNA in plasma of patients after allogeneic bone grafting \u00d6. 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