{"id":25165,"date":"2023-10-23T12:10:51","date_gmt":"2023-10-23T10:10:51","guid":{"rendered":"https:\/\/botiss.com\/?post_type=product&p=25165"},"modified":"2024-07-24T09:59:58","modified_gmt":"2024-07-24T07:59:58","slug":"evaluation-between-biodegradable-magnesium-metal-gbr-membrane-and-bovine-graft-with-or-without-hyaluronate","status":"publish","type":"product","link":"https:\/\/botiss.com\/de\/produkt\/evaluation-between-biodegradable-magnesium-metal-gbr-membrane-and-bovine-graft-with-or-without-hyaluronate\/","title":{"rendered":"Evaluation between Biodegradable Magnesium Metal GBR Membrane and Bovine Graft with or without Hyaluronate"},"content":{"rendered":"

Bla\u0161kovi\u0107 M, Bla\u0161kovi\u0107 D, Hangyasi DB, Peloza OC, Tomas M, \u010candrli\u0107 M, Rider P, Mang B, Ka\u010darevi\u0107 \u017dP, Trajkovski B. Membranes. 2023; 13(8):691.<\/b>
\n<\/b><\/span>https:\/\/doi.org\/10.3390\/membranes13080691<\/u><\/a><\/h4>\n

GOAL<\/strong><\/p>\n

In this study, possible effects of the hyaluronate contained in cerabone\u00ae +HyA on the degradation rate of the NOVAMag\u00ae membrane were investigated.<\/p>\n

METHODS<\/strong><\/p>\n

To study the interaction between the biomaterials, in vitro tests were performed, and clinical results were retrospectively analyzed.<\/p>\n

In vitro, the fate of the magnesium membrane was studied by measuring changes in pH and electric conductivity as indicators of membrane degradation. To this end, the NOVAMag\u00ae membranes were incubated in phosphate-buffered saline over a period of 360 h at room temperature, either alone or in presence of bovine bone graft with hyaluronate (cerabone\u00ae +HyA) or without (cerabone\u00ae).<\/p>\n

The clinical evaluation considered two patients that underwent implant surgery and simultaneous Guided Bone Regeneration (GBR) in the lower jaw using the magnesium membrane in combination with either cerabone\u00ae +HyA or cerabone\u00ae, both mixed with autogenous bone chips.<\/p>\n

RESULTS<\/strong><\/p>\n

In vitro<\/span>
\nNo effects of the bone grafts on the pH of the magnesium membrane were observed. The results on the measured pH values demonstrated that the hyaluronate contained in cerabone\u00ae +HyA did not induce an acidic environment that could increase the rate of degradation of the membrane.<\/p>\n

Different electric conductivity profiles were noticed caused by the release of calcium and magnesium ions by the tested biomaterials, thus indicating the formation of degradation products. The combination of cerabone\u00ae +HyA and NOVAMag\u00ae membrane caused a decrease in the conductivity in the first 24 h, which subsequently increased and remained stable after 96 h, thus suggesting a synergistically delayed calcium and magnesium release.<\/p>\n

Clinical<\/span>
\nBoth patients treated with the biomaterials combinations showed excellent clinical outcomes both in terms of soft- and hard tissue regeneration. CBCT analyses six months post-operative demonstrated stable osteointegration of the placed implants.<\/p>\n

CONCLUSIONS<\/strong><\/p>\n