{"id":50842,"date":"2025-07-09T12:53:04","date_gmt":"2025-07-09T10:53:04","guid":{"rendered":"https:\/\/botiss.com\/?post_type=product&p=50842"},"modified":"2025-07-11T15:14:29","modified_gmt":"2025-07-11T13:14:29","slug":"association-of-vitamin-d-level-and-periodontitis-a-comprehensive-review","status":"publish","type":"product","link":"https:\/\/botiss.com\/es\/producto\/association-of-vitamin-d-level-and-periodontitis-a-comprehensive-review\/","title":{"rendered":"Association of Vitamin D level and periodontitis: a comprehensive review"},"content":{"rendered":"

Crni\u0107, T., Ka\u0161aj, A. Association of Vitamin D level and periodontitis: a comprehensive review. Periodontal and Implant Res.<\/i> 8, 14 (2024). https:\/\/doi.org\/10.1007\/s41894-024-00143-6<\/p>\n

https:\/\/doi.org\/10.1093\/nutrit\/nuac068<\/a><\/p>\n

ABSTRACT<\/strong><\/p>\n

Context<\/strong><\/p>\n

There is still controversy over the effect of vitamin D3<\/sub> supplementation on bone health.<\/p>\n

Objective<\/strong><\/p>\n

The effects of vitamin D3<\/sub> supplementation on bone mineral density (BMD) and markers of bone turnover, as well as the dose-response relationship between vitamin D3<\/sub> and bone health in adults, were evaluated.<\/p>\n

Data Sources<\/strong><\/p>\n

The PubMed, Scopus, Cochrane, Web of Science, and AGRIS databases were searched for articles published through April 30, 2022. Thirty-nine of the 6409 records identified met the inclusion criteria<\/p>\n

Data Extraction<\/strong><\/p>\n

Data were extracted from articles by 2 authors, and data extraction was cross-checked independently. A random-effects model was used to estimate the pooled effect size and the associated 95%CI for the effect of vitamin D3<\/sub> for each outcome. A one-stage random-effects dose-response model was used to estimate the dose-response relationship between vitamin D3<\/sub> supplementation and BMD.<\/p>\n

Data Analysis<\/strong><\/p>\n

Results of meta-analysis showed a beneficial effect of vitamin D3<\/sub> at the lumbar spine (standardized mean difference [SMD]\u2005=\u20050.06; 95%CI, 0.01\u20130.12) and femoral neck (SMD\u2005=\u20050.25; 95%CI, 0.09\u20130.41). Dose-response analysis revealed a linear relationship between vitamin D3<\/sub> supplementation doses and BMD at the femoral neck, lumbar spine, and total hip sites. No significant effect of vitamin D3<\/sub> supplementation on whole-body or total hip BMD was observed (P<\/em>\u2009<\/em>>\u2009<\/em>0.05). Vitamin D3<\/sub>supplementation significantly decreased BMD at both proximal and distal forearm (SMD\u2005=\u2005\u22120.16; 95%CI, \u22120.26 to \u22120.06). The variables of ethnicity, age, baseline 25-hydroxyvitamin D (25[OH]D), menopause status, vitamin D3<\/sub> dosing frequency, and bone health status (P<\/em> interaction\u2009=\u20090.02) altered the effect of vitamin D3<\/sub>supplementation on BMD. Additionally, a nonlinear relationship between vitamin D3<\/sub> supplement doses and markers of bone turnover was found.<\/p>\n

Conclusion<\/strong><\/p>\n

A protective effect of vitamin D3<\/sub> supplementation on BMD of the lumbar spine, femoral neck, and total hip is implicated.<\/p>\n

Systematic Review Registration<\/p>\n

PROSPERO registration number CRD42017054132.<\/p>\n

bone mineral density, cholecalciferol, osteoporosis<\/p>\n

Topic:<\/strong><\/p>\n