{"id":11889,"date":"2016-04-01T10:45:00","date_gmt":"2016-04-01T08:45:00","guid":{"rendered":"https:\/\/botiss.com\/product\/pre-clinical-article-published-by-stahli-et-al-2\/"},"modified":"2024-07-24T10:00:16","modified_gmt":"2024-07-24T08:00:16","slug":"pre-clinical-article-published-by-stahli-et-al-2","status":"publish","type":"product","link":"https:\/\/botiss.com\/fr\/produit\/pre-clinical-article-published-by-stahli-et-al-2\/","title":{"rendered":"Pre-clinical article published by St\u00e4hli et al."},"content":{"rendered":"

Collagen Membranes Adsorb the Transforming Growth Factor-\u03b2 Receptor I Kinase-Dependent Activity of Enamel Matrix Derivative
\nSt\u00e4hli A, Miron RJ, Bosshardt DD, Sculean A, Gruber R
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26777762<\/span><\/a><\/span><\/h4>\n

Background:<\/span>
\nEnamel matrix derivative (EMD) and collagen membranes (CMs) are simultaneously applied in regenerative periodontal surgery. The aim of this study is to evaluate the ability of two CMs and a collagen matrix to adsorb the activity intrinsic to EMD that provokes transforming growth factor (TGF)-\u03b2 signaling in oral fibroblasts.<\/p>\n

Methods:<\/span>
\nThree commercially available collagen products were exposed to EMD or recombinant TGF-\u03b21, followed by vigorous washing. Oral fibroblasts were either seeded directly onto collagen products or were incubated with the respective supernatant. Expression of TGF-\u03b2 target genes interleukin (IL)-11 and proteoglycan 4 (PRG4) was evaluated by real time polymerase chain reaction. Proteomic analysis was used to study the fraction of EMD proteins binding to collagen.<\/p>\n

Results:<\/span>
\nEMD or TGF-\u03b21 provoked a significant increase of IL-11 and PRG4 expression of oral fibroblasts when seeded onto collagen products and when incubated with the respective supernatant. Gene expression was blocked by the TGF-\u03b2 receptor I kinase inhibitor SB431542. Amelogenin bound most abundantly to gelatin-coated culture dishes. However, incubation of palatal fibroblasts with recombinant amelogenin did not alter expression of IL-11 and PRG4.<\/p>\n

Conclusion:<\/span>
\nThese in vitro findings suggest that collagen products adsorb a TGF-\u03b2 receptor I kinase-dependent activity of EMD and make it available for potential target cells.<\/p>\n

Alexandra St\u00e4hli<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Collagen Membranes Adsorb the Transforming Growth Factor-\u03b2 Receptor I Kinase-Dependent Activity of Enamel Matrix Derivative St\u00e4hli A, Miron RJ, Bosshardt DD, Sculean A, Gruber R https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26777762 Background: Enamel matrix derivative …<\/p>\n","protected":false},"featured_media":11532,"template":"","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"product_brand":[],"product_cat":[2063,2059],"product_tag":[1917,1902,3883,1935],"class_list":["post-11889","product","type-product","status-publish","has-post-thumbnail","product_cat-scienza","product_cat-studi","product_tag-membrana-collprotect","product_tag-membrana-jason-it","product_tag-recession-defects","product_tag-gestione-dei-tessuti-molli","first","instock","product-type-simple"],"acf":[],"yoast_head":"\nPre-clinical article published by St\u00e4hli et al. - botiss biomaterials GmbH<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/botiss.com\/fr\/produit\/pre-clinical-article-published-by-stahli-et-al-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pre-clinical article published by St\u00e4hli et al.\" \/>\n<meta property=\"og:description\" content=\"Collagen Membranes Adsorb the Transforming Growth Factor-\u03b2 Receptor I Kinase-Dependent Activity of Enamel Matrix Derivative St\u00e4hli A, Miron RJ, Bosshardt DD, Sculean A, Gruber R https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26777762 Background: Enamel matrix derivative ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/botiss.com\/fr\/produit\/pre-clinical-article-published-by-stahli-et-al-2\/\" \/>\n<meta property=\"og:site_name\" content=\"botiss biomaterials GmbH\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/botissdental\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-24T08:00:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/botiss.com\/wp-content\/uploads\/2023\/02\/mucoderm_emdogain.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@BotissB\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/botiss.com\\\/fr\\\/produit\\\/pre-clinical-article-published-by-stahli-et-al-2\\\/\",\"url\":\"https:\\\/\\\/botiss.com\\\/fr\\\/produit\\\/pre-clinical-article-published-by-stahli-et-al-2\\\/\",\"name\":\"Pre-clinical article published by St\u00e4hli et al. - 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