{"id":38684,"date":"2024-09-03T10:05:33","date_gmt":"2024-09-03T08:05:33","guid":{"rendered":"https:\/\/botiss.com\/?post_type=product&p=38684"},"modified":"2024-09-10T11:28:12","modified_gmt":"2024-09-10T09:28:12","slug":"a-comparative-analysis-of-particulate-bovine-bone-substitutes-for-oral-regeneration-a-narrative-review-with-cerabone","status":"publish","type":"product","link":"https:\/\/botiss.com\/fr\/produit\/a-comparative-analysis-of-particulate-bovine-bone-substitutes-for-oral-regeneration-a-narrative-review-with-cerabone\/","title":{"rendered":"A comparative analysis of particulate bovine bone substitutes for oral regeneration: a narrative review"},"content":{"rendered":"

https:\/\/pubmed.ncbi.nlm.nih.gov\/38801622\/<\/strong><\/a>
\nPabst A, Becker P, G\u00f6tz W, Heimes D, Thiem DGE, Blatt S, K\u00e4mmerer PW. Int J Implant Dent. 2024 May 27;10(1):26.<\/p>\n

OBJECTIVES<\/strong><\/h4>\n

Pre-clinical and clinical studies that compare a minimum of two different particulate bovine bone substitute materials for dental bone regeneration were analyzed with respect to production process, physicochemical characteristics, resorption properties, and performance of the bone substitutes by conducting a systematic search in PubMed database.<\/p>\n

RESULTS<\/strong><\/h4>\n

Bovine bone substitutes can be distinguished by their manufacturing processes.<\/strong><\/p>\n

Bovine bone substitutes can generally be separated into two groups based on their manufacturing processes. The bone raw material is either processed by applying elevated temperatures (> 1000\u00b0C; high temperature treated bovine bone substitute) or is treated at low temperatures including additional chemical cleaning (low temperature treated bovine bone substitute).<\/p>\n

Low and high temperature treated bovine bone substitute materials have different properties.<\/strong><\/p>\n

The found data demonstrate differences between the bone substitutes concerning porosity, crystallinity, and calcium release rate, which can be correlated with their different production processes.<\/p>\n

The analyzed pre-clinical and clinical studies have shown slight differences in the performance of the bone substitutes. A summary of the results of the found and evaluated data is provided in Table 1.<\/p>\n

Table 1. Summary of the results of the found pre-clinical and clinical data:<\/strong><\/p>\n<\/div><\/div><\/div><\/div><\/div>

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\nLow temperature treated bovine bone substitute (BS)<\/span><\/strong><\/td>\nHigh temperature treated bovine bone substitute (BS)<\/span><\/strong><\/td>\n<\/tr>\n
Physicochemical properties<\/span><\/strong><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
Crystallinity (Crystal size compared to human bone)<\/span><\/td>\n\n

Increased by 200 \u2013 300%<\/p>\n<\/td>\n

\n

Increased by 500 \u2013 1000%<\/p>\n<\/td>\n<\/tr>\n

Calcium\/phosphate ratio<\/span><\/td>\n\n

Both ranging from 1.74 to 1.33<\/p>\n<\/td>\n<\/tr>\n

Calcium release<\/span><\/td>\n\n

12 mg\/g<\/p>\n<\/td>\n

\n

4 mg\/g<\/p>\n<\/td>\n<\/tr>\n

Resorption<\/span><\/td>\n\n

Both minimal to negligible<\/p>\n<\/td>\n<\/tr>\n

Pre-clinical data<\/span><\/strong><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
In vitro<\/span><\/td>\nSlight evidence of minor advantages of high temperature treated BS, such as improved biocompatibility in cell cultures.<\/span><\/td>\n<\/tr>\n
In vivo<\/span><\/td>\nSubtle tendency towards variances in new bone formation between low and high temperature treated bovine BS across distinct healing intervals with potential slight benefits favoring high temperature treated bovine BS after 2\u20133 months.<\/span><\/td>\n<\/tr>\n
Clinical data<\/span><\/strong><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
Ridge preservation<\/span><\/td>\n\n
    \n
  • No significant differences regarding the efficacy of different particulate bovine BS for ridge preservation<\/span><\/li>\n
  • A RCT showed marginal benefits of low temperature treated bovine BS over high temperature treated BS in ridge preservation, specifically in crestal gingival healing, transversal crestal ridge resorption, and primary implant stability.<\/span><\/li>\n
  • Available data are inadequate to support an evidence-based conclusion<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
Sinus lift<\/span><\/td>\n\n
    \n
  • Low-temperature treated BS tented to an increased long-time bone volume loss.<\/span><\/li>\n
  • High-temperature-treated BS seemed to improve new bone formation and decrease the amount of connective tissue.<\/span><\/li>\n
  • The potential differences between bovine-derived BS are only evident or by trend in individual studies and do not permit evidence-based conclusions.<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
Peri-implant bone defects<\/span><\/td>\n\n
    \n
  • The available data does not suggest relevant differences between different particulate bovine BS for both indications.<\/span><\/li>\n
  • No evidence-based assessment possible due to the available data.<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
Lateral\/vertical alveolar ridge augmentation<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/div><\/div>

CONCLUSIONS<\/strong><\/h4>\n

Different manufacturing processes of particulate bovine bone substitute materials lead to different material properties.<\/p>\n

Found and analyzed pre-clinical studies comparing at least two particulate bone substitute materials have demonstrated slight favorable outcomes for high temperature treated bovine bone substitutes.<\/p>\n

No significant differences were noted for clinical outcomes based on the found comparative studies, except for sinus floor augmentation, which is that there is a trend towards small benefits with high temperature treated bovine bone substitute regarding volume loss, new bone formation and the amount of connective tissue.<\/p>\n

However, data directly comparing particulate bovine bone substitutes are scarce, therefore additional clinical studies are required.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":38685,"template":"","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"product_brand":[],"product_cat":[2044,2048],"product_tag":[1929,2887,1927],"class_list":["post-38684","product","type-product","status-publish","has-post-thumbnail","product_cat-science-fr","product_cat-etudes","product_tag-cerabone-fr","product_tag-ridge-augmentation","product_tag-reconstruction-de-la-crete","first","instock","product-type-simple"],"acf":[],"yoast_head":"\nA comparative analysis of particulate bovine bone substitutes for oral regeneration: a narrative review - botiss biomaterials GmbH<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/botiss.com\/fr\/produit\/a-comparative-analysis-of-particulate-bovine-bone-substitutes-for-oral-regeneration-a-narrative-review-with-cerabone\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A comparative analysis of particulate bovine bone substitutes for oral regeneration: a narrative review\" \/>\n<meta property=\"og:url\" content=\"https:\/\/botiss.com\/fr\/produit\/a-comparative-analysis-of-particulate-bovine-bone-substitutes-for-oral-regeneration-a-narrative-review-with-cerabone\/\" \/>\n<meta property=\"og:site_name\" content=\"botiss biomaterials GmbH\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/botissdental\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-10T09:28:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/botiss.com\/wp-content\/uploads\/2024\/09\/PABST_CAMPUS_1200x800.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@BotissB\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/botiss.com\\\/fr\\\/produit\\\/a-comparative-analysis-of-particulate-bovine-bone-substitutes-for-oral-regeneration-a-narrative-review-with-cerabone\\\/\",\"url\":\"https:\\\/\\\/botiss.com\\\/fr\\\/produit\\\/a-comparative-analysis-of-particulate-bovine-bone-substitutes-for-oral-regeneration-a-narrative-review-with-cerabone\\\/\",\"name\":\"A comparative analysis of particulate bovine bone substitutes for oral regeneration: a narrative review - 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