{"id":30336,"date":"2024-01-18T09:43:11","date_gmt":"2024-01-18T08:43:11","guid":{"rendered":"https:\/\/botiss.com\/?p=30336"},"modified":"2024-01-19T11:09:00","modified_gmt":"2024-01-19T10:09:00","slug":"vitamin-d-for-the-prevention-of-oral-cancer","status":"publish","type":"post","link":"https:\/\/botiss.com\/it\/vitamin-d-for-the-prevention-of-oral-cancer\/","title":{"rendered":"Vitamin D for the prevention of oral cancer"},"content":{"rendered":"

The role of vitamin D as an important player in health and the regulation of the immune system has been known for years 1<\/sup>. Especially in winter, an adequate supply of vitamin D supports the body’s defenses and reduces the risk of respiratory infections 2<\/sup>. Also in the case of oral dysplasia, which are characterized as precursors to malignant oral cancer, vitamin D appears to be of increasing importance 3<\/sup>.<\/strong><\/span><\/p>\n

These so-called OPMDs (oral potentially malignant disorders) are characterized by histopathologically specific lesions in the oral cavity. The latest data underlines the link between vitamin D deficiency and the development of oral dysplasia and the risk of malignant oral cancer 3<\/sup>. It is already known that vitamin D supports the physical barrier in the oral cavity and contributes to functional oral health 4<\/sup>. In this context it is also important to note that vitamin D can both inhibit and permanently alter the growth of cancer cells and induce cell death 5\u20137<\/sup>. Furthermore, vitamin D is able to reduce the production of pro-inflammatory molecules and initiate anti-inflammatory processes so that chronic inflammation, which plays a decisive role in the development of cancer, is prevented 3<\/sup>. Vitamin D has numerous effects and enables a variety of therapeutic concepts that can be implemented in the future. A vitamin D-rich diet, by an addition of vitamin D in food as well as in the form of separate supplements, could prove to be a valid strategy to reduce the probability of malignant progression 3<\/sup>. Therefore, determination and optimization of vitamin D levels can help to minimize the risk of disease and improve oral health.<\/p>\n

 <\/p>\n

References<\/strong><\/p>\n

    \n
  1. Charoenngam, N. & Holick, M. F. Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients<\/em> 12<\/strong>, 2097 (2020).<\/li>\n
  2. Hamza, F. N. et al.<\/em> Immunomodulatory Properties of Vitamin D in the Intestinal and Respiratory Systems. Nutrients<\/em> 15<\/strong>, 1696 (2023).<\/li>\n
  3. Khamis, A., Salzer, L., Schiegnitz, E., Stauber, R. H. & G\u00fcl, D. The Magic Triangle in Oral Potentially Malignant Disorders: Vitamin D, Vitamin D Receptor, and Malignancy. Int J Mol Sci<\/em> 24<\/strong>, (2023).<\/li>\n
  4. Jagelavi\u010dien\u0117, E., Vaitkevi\u010dien\u0117, I., \u0160ilingait\u0117, D., \u0160ink\u016bnait\u0117, E. & Daug\u0117lait\u0117, G. The relationship between vitamin D and periodontal pathology. Medicina (Lithuania)<\/em> vol. 54 Preprint at https:\/\/doi.org\/10.3390\/medicina54030045 (2018).<\/li>\n
  5. Fern\u00e1ndez-Barral, A. et al.<\/em> Vitamin D Effects on Cell Differentiation and Stemness in Cancer. Cancers 2020, Vol. 12, Page 2413<\/em> 12<\/strong>, 2413 (2020).<\/li>\n
  6. Samuel, S. & Sitrin, M. D. Vitamin D\u2019s role in cell proliferation and differentiation. Nutr Rev<\/em> 66<\/strong>, S116\u2013S124 (2008).<\/li>\n
  7. Snegarova, V. & Naydenova, D. Vitamin D: a Review of its Effects on Epigenetics and Gene Regulation. Folia Med (Plovdiv)<\/em> 62<\/strong>, 662\u2013667 (2020).<\/li>\n<\/ol>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

    The role of vitamin D as an important player in health and the regulation of the immune system has been known for years.<\/p>\n","protected":false},"author":2,"featured_media":30330,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"categories":[1045],"tags":[],"class_list":["post-30336","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"yoast_head":"\nVitamin D for the prevention of oral cancer - botiss biomaterials GmbH<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/botiss.com\/it\/vitamin-d-for-the-prevention-of-oral-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vitamin D for the prevention of oral cancer\" \/>\n<meta property=\"og:description\" content=\"The role of vitamin D as an important player in health and the regulation of the immune system has been known for years.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/botiss.com\/it\/vitamin-d-for-the-prevention-of-oral-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"botiss biomaterials GmbH\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/botissdental\" \/>\n<meta property=\"article:published_time\" content=\"2024-01-18T08:43:11+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-19T10:09:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/botiss.com\/wp-content\/uploads\/2024\/01\/AdobeStock_471879400_1200x800.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"henning\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@BotissB\" \/>\n<meta name=\"twitter:site\" content=\"@BotissB\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"henning\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/botiss.com\\\/it\\\/vitamin-d-for-the-prevention-of-oral-cancer\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/botiss.com\\\/it\\\/vitamin-d-for-the-prevention-of-oral-cancer\\\/\"},\"author\":{\"name\":\"henning\",\"@id\":\"https:\\\/\\\/botiss.com\\\/it\\\/#\\\/schema\\\/person\\\/9465ef7d5a8b65c7c13900f7fc1ffd4c\"},\"headline\":\"Vitamin D for the prevention of oral cancer\",\"datePublished\":\"2024-01-18T08:43:11+00:00\",\"dateModified\":\"2024-01-19T10:09:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/botiss.com\\\/it\\\/vitamin-d-for-the-prevention-of-oral-cancer\\\/\"},\"wordCount\":532,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/botiss.com\\\/it\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/botiss.com\\\/it\\\/vitamin-d-for-the-prevention-of-oral-cancer\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/botiss.com\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/AdobeStock_471879400_1200x800.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/botiss.com\\\/it\\\/vitamin-d-for-the-prevention-of-oral-cancer\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/botiss.com\\\/it\\\/vitamin-d-for-the-prevention-of-oral-cancer\\\/\",\"url\":\"https:\\\/\\\/botiss.com\\\/it\\\/vitamin-d-for-the-prevention-of-oral-cancer\\\/\",\"name\":\"Vitamin D for the prevention of oral cancer - 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