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New clinical study with cerabone® in regenerative periodontal surgery

Nonincised Papillae Surgical Approach (NIPSA) in Periodontal Regeneration: Preliminary Results of a Case Series.
Moreno Rodriguez JA, Caffesse RG. Int J Periodontics Restorative Dent. 2018;38(Suppl):s105-s111.


This case series aims to clinically evaluate a new surgical approach to treat periodontal intrabony defects in conjunction with cerabone® and Emdogain®. Surgically, the defects are accessed via the alveolar mucosa preserving the interdental tissues (Nonincised Papillae Surgical Approach, NIPSA).

Ten patients diagnosed with periodontal intrabony defects with a mean probing pocket depth (PPD) of 9.6 ± 2.3 mm were treated with the Nonincised Surgical Approach (NIPSA) in conjunction with cerabone® and Emdogain®. PPD reduction, clinical attachment level gain (CAL), keratinized tissue width and recessions were recorded six to 18 months post-surgery.

Healing was uneventful in all cases. PPD decreased to 2.3 ± 0.5 mm and a CAL gain of 7.3 ± 2.4 mm was found. Gingival papilla height, keratinized tissue width and buccal gingival margin remained stable over time. All defects presented negative bleeding on probing.

Deep isolated intrabony defects can be successfully treated using the Nonincised Surgical Approach (NIPSA) in conjunction with cerabone® and Emdogain®. NIPSA preserves the interdental papillae and marginal keratinized tissues avoiding post-operative soft tissue shrinkage.