In vitro evaluation of an injectable biphasic calcium phosphate (BCP) carrier system combined with recombinant human bone morphogenetic protein (rhBMP)-9.
Bio-Medical Materials and Engineering 28 (2017) 293–304.
Fujioka-Kobayashi et al.
https://www.ncbi.nlm.nih.gov/pubmed/28527192

Study aim and design:
The study evaluated the possibility of combining maxresorb® inject with growth factors by analyzing adsorption of rhBMP9 as well as adhesion, proliferation, viability and differentiation of stromal cells.

Results:
The results demonstrated that maxresorb inject serves as an excellent carrier for the growthfactors. The bone paste showed very good adsorption/retention potential of rhBMP9 with a slow and steady release over a 10 day period. The combination of maxresorb® inject and rhBMP9 demonstrated a good osteoinductive potential by positively influencing the osteoblastic differentiation of stromal cells.

Masako Fujioka-Kobayashi