collafleece®

RESORBABLE COLLAGEN FOR WOUND MANAGEMENT

wet-stable porcine collagen sponge

Natural homeostasis

Maintains integrity

collafleece® is a wet-stable, porcine collagen sponge with highly efficient hemostatic properties. Its natural porous collagen structure supports the hemostasis and controls the natural healing of the wound 1. Owing to its spongy structure, the collafleece® resorbs within ~2-4 weeks 2.

FAST HEMOSTASIS AND STABILIZATION OF THE BLOOD CLOT

The efficacy of collafleece® is based on the well-known characteristics of collagen. The process of blood clotting comprises a complex series of reactions induced by the adhesion of platelets to the collagen fibers, which results in the formation of a thrombus by platelet aggregation. The secretion of coagulation factors is thereby triggered, which initiate further reactions as the formation of a fibrin clot 3-5. The fast clotting reaction through collafleece® is particularly helpful when treating hemostatic compromised patients 1.

Product Specifications

Art.-No. Size Content
512212 20 x 20 mm 12 pieces

Distribution

With our international network of distribution partners, we are near you in over 100 countries worldwide. In addition to our 360° productportfolio, we offer service, scientific advice and exchange, training and events directly on site from a single source.

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SPECIFIC FACTS

collafleece® is produced in a certified process from the porcine dermis. The unique manufacturing process provides a safe and cell-free product that is regulated according to the EC guidelines. Its natural hemostatic effect and the fast resorption making collafleece® an excellent medical device for the treatment of oral wounds.

Damage to the blood vessel wall leads to subendothelial collagen release. The collagen directly or indirectly interacts with the surface receptors on thrombocytes. The binding of collagen initiates a reaction cascade leading to transformation and aggregation of the thrombocytes. Additionally, the thrombocytes are cross-linked by fibrinogen. The resulting (white) thrombus initially stabilizes the wound. Accordingly, collagen membranes and sponges support the formation of a blood coagulum and contribute to a rapid stabilization of the wound area. Due to their hemostatic effect, collagen sponges and cones can be used for stabilization of biopsy harvesting sites or covering of minor oral wounds and extraction sockets, respectively.

Medication with anticoagulant drugs (i.e. heparin or warfarin) poses a risk for patients of bleeding following tooth extraction. Local hemostatic agents like collagen fleeces can prevent postoperative bleeding without the need to pause the anticoagulant therapy 1. A retrospective study with 200 anticoagulated patients showed a very low rate of bleedings following application of collagen sponges with a similar composition (collacone®).

A dry application of collafleece® is recommended because pre-hydration may impair its hemostatic properties. At the defect site, the fleece soaks up blood very quickly but maintains its integrity. A direct fixation by sutures/pins is not possible, but also not necessary. Indirect fixation, on the other hand, by cross- or holding sutures could help keeping the fleece in place e.g. in extraction sockets or at soft tissue harvesting sites.

collafleece® is a cost-effective alternative to barrier membranes during sinus floor elevations for the protection of the Schneiderian membrane. It can also be used to protect barrier membranes from fast bacterial resorption when an exposure is likely.

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PRODUCTOS RELACIONADOS

  • collacone®

    NATURAL COLLAGEN CONE FOR APPLICATION IN EXTRACTION SOCKETS

    A wet-stable and moldable cone made of natural collagen.

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botiss biomaterials GmbH

Hauptstrasse 28
15806 Zossen / Germany
Tel.: +49 33769 / 88 41 985
Fax: +49 33769 / 88 41 986
  1. Zirk et al. 2016. Prevention of post-operative bleeding in hemostatic compromised patients using native porcine collagen fleeces-retrospective study of a consecutive case series. Oral Maxillofac Surg. 20(3):249-54.
  2. Barbeck et al. 2015. Porcine Dermis and Pericardium-Based, Non-Cross-Linked Materials Induce Multinucleated Giant Cells After Their In Vivo Implantation: A Physiological Reaction? J Oral Implantol. 41(6):e267-81
  3. Nieswandt B and Watson SP. Platelet-collagen interaction: is GPVI the central receptor? Blood. 2003; 15;102(2):449-61. http://www.ncbi.nlm.nih.gov/pubmed/12649139
  4. Nuyttens BP, Thijs T, Deckmyn H, Broos K. Platelet adhesion to collagen. Thromb Res. 2011; 127 Suppl 2:S26-9. http://www.ncbi.nlm.nih.gov/pubmed/21193111
  5. Versteeg H.H, Heemskerk J.W.M, Levi M, Reitsma P.H. New fundamentals in hemostasis. Physiological Reviews 2013; 93(1): 327-358.