NOVAMag® membrane


Resorbable barrier membrane

Biodegradable metal

Controlled degradation

The magnesium membrane is strong and resorbable at the same time. It can be trimmed to size and shaped for treating individual bone defects. Because the NOVAMag® membrane is completely resorbed within a few months after implantation, a second surgical intervention to remove the membrane is not necessary

Mechanically Strong and resorbable

The NOVAMag® membrane is produced from pure magnesium metal. Magnesium is a biodegradable metal that is resorbed by the human body without toxic residuals1-3. Magnesium ions (Mg2+) released during the degradation process are a naturally occurring component in the human body and are responsible for many physiological processes4-6. Due to the inherent properties of magnesium metal, the NOVAMag® membrane provides a mechanically strong yet degradable material option for bone augmentation surgeries7-8. It is ideal for protecting bone defect voids during bone regeneration and maintaining the positioning of autologous bone and bone augmentation materials such as cerabone®.

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Product Specifications

Art.-No. Package Size Dimensions
721520 S 15 x 20 mm
722030 M 20 x 30 mm
723040 L 30 x 40 mm


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Biodegradable metals are a class of metal that when implanted will gradually degrade and be completely resorbed. The degradation products are then metabolized by the human body.

The NOVAMag® membrane has a smooth and shiny surface. Immediately upon implantation, the membrane begins to degrade. The degradation process creates a rough surface that improves the adhesion of the soft tissues.

As the magnesium metal degrades, magnesium salts and hydrogen gas are formed at the surface. The combination of the magnesium metal and the magnesium salts provide an effective barrier during the critical healing period7-8. In some instances, hydrogen gas slightly tents the soft tissue above the NOVAMag® membrane, thereby providing as an additional barrier without affecting bone regeneration.

The NOVAMag® membrane will be completely degraded within a few months after its implantation7-8.

During the degradation of the magnesium metal, the metallic structure is transformed into magnesium salts and a small volume of hydrogen gas is released. A small accumulation of the gas may collect around each device and is visible in X-rays8. The release of hydrogen gas might present as a slight swelling of the soft tissues.

The magnesium salts keep the original shape and position of the membrane until they are resorbed by the body, whereas the small volume of hydrogen gas initially provides a slight tenting of the soft tissue7-8. Both of these degradation by-products continue to maintain a separation of the soft and hard tissues as a second phase to the barrier functionality of the membrane until they are resorbed by the body.

Animal studies have shown that NOVAMag® membrane is usually resorbed within 8-16 weeks after implantation. In an in-vivo performance study, a similar barrier function was observed in comparison to a collagen membrane, with similar volumes of new bone and soft tissue within the defect at every timepoint8.
It is recommended that the NOVAMag® membrane is secured using the NOVAMag® fixation screw XS. In some instances the NOVAMag® membrane can also be secured using the NOVAMag® fixation screw S-XL.

However, it is also possible to use the Membrane Fixation Screw, USTOMED Instrumente Ulrich Storz GmbH & Co. KG or the Pro-fix™ Precision Fixation System, Osteogenics Biomedical Inc.

For instances of exposure, it is recommended that special care is taken for controlling oral hygiene, rinsing the area with e.g. CHX solutions, and avoiding acidic food and/or drink as well as smoking. No additional treatment measures for the soft tissue is required. Cases of small dehiscence should disappear after 2-3 weeks. There is no need for membrane removal in the case of localized exposure.

Upon exposure, the membrane can appear dark grey/ black in colour, which happens normally during the degradation process.


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  • NOVAMag® fixation screw

    Resorbable, biodegradable, magnesium metal alloy

    Ideal for securing barrier membranes, bone grafts and bone augmenting material

  • NOVAMag® Instruments

    Optimal handling for all magnesium products

    To ensure optimal handling of the NOVAMag® membrane and the NOVAMag® fixation screw, botiss has developed a range of NOVAMag® instruments in close cooperation with clinicians.

  • permamem®


    An exceptionally thin, non-resorbable and biocompatible membrane.


Send your questions about our products directly to our specialists:

Product Management

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botiss biomaterials GmbH

Hauptstrasse 28
15806 Zossen / Germany
Tel.: +49 33769 / 88 41 985
Fax: +49 33769 / 88 41 986
  1. D. Zhao, F. Witte, F. Lu, J. Wang, J. Li, and L. Qin, “Current status on clinical applications of magnesium-based orthopaedic implants: A review from clinical translational perspective,” Biomaterials, vol. 112. Elsevier Ltd, pp. 287–302, Jan. 01, 2017. doi: 10.1016/j.biomaterials.2016.10.017.
  2. K. Bobe et al., “In vitro and in vivo evaluation of biodegradable, open-porous scaffolds made of sintered magnesium W4 short fibres,” Acta Biomater., vol. 9, no. 10, pp. 8611–8623, Nov. 2013, doi: 10.1016/j.actbio.2013.03.035.
  3. E. Willbold et al., “Biocompatibility of rapidly solidified magnesium alloy RS66 as a temporary biodegradable metal,” Acta Biomater., vol. 9, no. 10, pp. 8509–8517, Nov. 2013, doi: 10.1016/j.actbio.2013.02.015.
  4. N. E. L. Saris, E. Mervaala, H. Karppanen, J. A. Khawaja, and A. Lewenstam, “Magnesium: An update on physiological, clinical and analytical aspects,” Clinica Chimica Acta, vol. 294, no. 1–2. Elsevier, pp. 1–26, Apr. 01, 2000. doi: 10.1016/S0009-8981(99)00258-2.
  5. J.-M. Seitz, R. Eifler, F.-W. Bach, and H. J. Maier, “Magnesium degradation products: Effects on tissue and human metabolism,” J. Biomed. Mater. Res. Part A, vol. 102, no. 10, pp. 3744–3753, Oct. 2014, doi: 10.1002/jbm.a.35023.
  6. J. Walker, S. Shadanbaz, T. B. F. Woodfield, M. P. Staiger, and G. J. Dias, “Magnesium biomaterials for orthopedic application: A review from a biological perspective,” Journal of Biomedical Materials Research – Part B Applied Biomaterials, vol. 102, no. 6. John Wiley and Sons Inc., pp. 1316–1331, Aug. 01, 2014. doi: 10.1002/jbm.b.33113.
  7. P. Rider et al., “Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery,” Bioact. Mater., vol. 14, pp. 152–168, Aug. 2022, doi: 10.1016/J.BIOACTMAT.2021.11.018.
  8. P. Rider et al., “Analysis of a Pure Magnesium Membrane Degradation Process and Its Functionality When Used in a Guided Bone Regeneration Model in Beagle Dogs,” Mater. 2022, Vol. 15, Page 3106, vol. 15, no. 9, p. 3106, Apr. 2022, doi: 10.3390/MA15093106.