JasonĀ® membrane

Native pericardium GRB/GTR membrane

remarkable tear resistance

Effective surface adaption

Naturally long barrier function

JasonĀ® membrane is a native collagen membrane obtained from porcine pericardium, developed and manufactured for dental bone and tissue regeneration. Besides its very low thickness it provides a naturally long barrier function based on the specific composition and structure of the pericardial collagen fibers 1,2. Owing to the preservation of the natural biomechanical properties of the pericardium, JasonĀ® membrane exhibits beneficial handling characteristics such as a remarkable tear resistance and effective surface adaptation3.

naturally long barrier function and favorable handling characteristics

Due to the unique production process, the superior properties of the native pericardium are preserved during the extensive cleaning procedure that is applied for the production of JasonĀ® membrane. Therefore, JasonĀ® membrane shows a natural honeycomb-like, multilayered collagen structure with an increased content of collagen type III leading to a remarkable tear resistance and slow degradation of JasonĀ® membrane 2, 4, 5, 6. This ensures a natural long barrier function, making the JasonĀ® membrane our recommended choice particularly for large augmentative procedures.

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JasonĀ® membrane offers a naturally long barrier function, which is especially advantageous for the regeneration of larger defects or more extended augmentative procedures. Moreover, due to its low thickness, JasonĀ® membrane is particularly beneficial in patients with thin biotypes or, generally, if a tension-free closure of the flap is difficult.

IMPLANTOLOGY, PERIODONTOLOGY AND ORAL AND CMF SURGERY

  • Horizontal and vertical augmentation
  • Ridge reconstruction
  • Socket and ridge preservation
  • Sinus lift
  • Protection and covering of Schneiderian membrane
  • Fenestration and dehiscence defects
  • Intraosseous defects (1 to 3 walls)
  • Furcation defects (class I and II)
REHYDRATION

JasonĀ® membrane can be applied dry or pre-hydrated in sterile saline solution or blood from the defect. The initial placement of the dry membrane with subsequent application of the graft material is particularly advantageous for lateral augmentations. After rehydration the membrane can be folded over the defect.

FIXATION

JasonĀ® membrane exhibits a remarkable multi-directional tear resistance. Therefore, it can easily be pinned, sutured or even screwed without rupturing. JasonĀ® membrane can also be applied in the sausage technique. Although fixation of JasonĀ® membrane is not required in many situations, due to its efficient surface adaptation, pinning of the membrane can help to prevent dislocation/migration of bone substitute particles.

EXPOSURE

Exposure of JasonĀ® membrane should be avoided, since fast bacterial resorption significantly reduces the barrier function of the thin JasonĀ® membrane. In case of an unstable soft tissue situation or if you expect a wound dehiscence to occur, it is recommended to cover the membrane with a collafleeceĀ® to protect the healing area. However, in case of a dehiscence the wound usually heals without complications by formation of free granulation tissue.

TRIMMING

JasonĀ® membrane can be cut to the desired shape and size with a pair of scissors – while maintaining sterility. It may be helpful to use appropriate templates for defining the required size of the membrane.

PLACEMENT

JasonĀ® membrane has one rough and one slightly smoother surface. The smoother, fine structured side is marked ā€žGā€œ at the top right corner and should be placed towards the gingiva. The rougher side should face the bone. However, there is no problem if the membrane is placed the other way around, since the long-term barrier function of the membrane will still provide sufficient protection for the regeneration site.

  • Naturally long barrier function
  • Multi-directional strength and tear resistance
  • No stickiness after rehydration
  • Excellent surface adaptation
  • Easy manipulation, can be applied dry or wet
  • Exceptionally thin (~0.15 mm)
  • No swelling after rehydration

Product Specifications

JasonĀ® membraneĀ is provided in the following dimensions:

Art.-No. Size Content
681520 15 x 20 mm 1 membrane
682030 20 x 30 mm 1 membrane
683040 30 x 40 mm 1 membrane

Distribution

With our international network of distribution partners, we are near you in over 100 countries worldwide. In addition to our 360Ā° productportfolio, we offer service, scientific advice and exchange, training and events directly on site from a single source.

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SPECIFIC FACTS

JasonĀ® membrane is a native collagen membrane derived from porcine pericardium (strong, elastic membrane that circumvents and protects the heart). During the extensive wet chemical cleaning procedure of the manufacturing process, all antigenic components are removed, but the natural structure of aligned collagen fibers and interconnected pores is preserved leading to slow degradation and prolonged stability 1, 2, 7.
According to the biomechanical properties of native pericardium, which is able to withstand significant volume changes and forces, the JasonĀ® membrane exhibits a remarkable tear resistance and stability 1, 2, 7. Hence, JasonĀ® membrane is characterized by an outstanding multi-directional tear resistance that allows easy pinning and suturing without rupturing and very good surface adaption without stickiness upon rehydration.
The thickness of a membrane does not necessarily correspond to its barrier function and resorption time. JasonĀ® membrane offers a very low thickness of 0.05-0.35 mm, but nevertheless exhibits a prolonged resorption time as proven by animal experiments 1, 2, 7.
The JasonĀ® membrane is a native collagen membrane, meaning the natural collagen structure of the pericardium is preserved during the manufacturing process. Due to the comb-like and multilayered collagen structure with an increased content of collagen type III, the JasonĀ® membrane shows a slow degradation 1,2, 7, 8. This ensures a prolonged barrier function, making the JasonĀ® membrane our recommended choice particularly for large augmentative procedures.
JasonĀ® membrane is not artificially cross-linked by chemical or physical treatment. Cross-linking slows down the membrane degradation properties but may negatively affects the biocompatibility, tissue integration, and revascularization as shown for other collagen membranes by an animal study 9. In opposite to chemically or physically cross-linked membranes, JasonĀ® membrane is characterized by a naturally long barrier function based on its origin from pericardial tissue 1. The fibers of the original pericardial tissue are naturally cross-linked4, their structure being preserved during the entire production process, thus generating a natural collagen membrane with an extended degradation time.
JasonĀ® membrane is hydrophilic and rapidly rehydrates in blood. The excellent ability of JasonĀ® membrane to adhere to the defect site without sticking together when folded guarantees optimal handling. The excellent adhesion to the defect site makes additional fixation of the membrane unnecessary in most cases. If wished or necessary, the multidirectional strength and tear resistance of JasonĀ® membrane permits the use of sutures and other fixation methods (e.g. pinning).
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botiss biomaterials GmbH

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Tel.: +49 33769 / 88 41 985
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  1. Rothamel et al. 2012. Biocompatibility and Biodegradation of a Native, Porcine Pericardium Membrane. Results from in vitro/in vivo Examination. J. Int J Oral Maxillofac Implants 2012, 27(1):146-54.
  2. Barbeck et al. 2015. Porcine dermis and pericardium-based, non-cross-linked materials induce multinucleated giant cells after their in vivo implantation: A physiological reaction? J Oral Implantol. 41(6):e267-81.
  3. Testing on tear resistance and suture pull-out force, data on file
  4. Braga-Vilela et al. 2008. Extracellular matrix of porcine pericardium: biochemistry and collagen architecture. J Membrane Biol. 221(1):15-25.
  5. Pabst et al. 2020. Collagen matrices: opportunities and perspectives in oral hard and soft tissue regeneration. Quintessence Int., 51(4):318-327.
  6. Naimark et al. Correlation of structure and viscoelastic properties in the pericardia of four mammalian species. Am J Physiol. 1992 Oct;263(4 Pt 2):H1095-106.
  7. Rothamel, D., Fienietz, T., Benner, M., Happe, A., Kreppel, M., Scheer, M., Zƶller, J. (2011), Poster EAO, Biodegradation pattern of native and cross-linked porcine collagen matrices ā€“ an experimental study in rats
  8. Pabst et al. 2020. Collagen matrices: opportunities and perspectives in oral hard and soft tissue regeneration. Quintessence Int., 51(4):318-327.
  9. Rothamel D, Schwarz F, Sager M, Herten M, Sculean A, Becker J. Biodegradation of differently cross-linked collagen membranes: an experimental study in the rat. Clin Oral Implants Res. 2005 Jun;16(3):369-78.