cerabone® plus

NATURAL BOVINE BONE SUBSTITUTE MATERIAL WITH HYALURONATE

sticky bone

time-saving application

long-term volume stability

cerabone® plus combines the established bovine bone grafting material cerabone® with the well-known properties of hyaluronic acid. Thanks to the pronounced liquid binding capacities of hyaluronate, cerabone® plus forms a sticky bone material upon hydration that provides unique application comfort by allowing both easy uptake and delivery to the site of application.

APPLICATION

cerabone® plus requires hydration before use (approx. 0.5 ml saline solution or patient blood per 1 ml cerabone® plus), which can conveniently be performed in the provided blister.
Optimal consistency can be tailored to the specific needs by adjustment of liquid volume. E.g. adding slightly less liquid results in a more stable consistency, while adding more liquid enables better dispersion.

Hyaluronic Acid

Boosting dental regeneration

Learn more about hyaluronic acid’s significance in tissue homeostasis and its use in biomaterials.

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IMPLANTOLOGY, PERIODONTOLOGY AND ORAL AND CMF SURGERY

  • Horizontal and vertical augmentation
  • Peri-implant defects
  • Periodontal intrabony defects
  • Socket and ridge preservation
  • Sinus lift
  • Furcation defects (class I and II)
Hydration

If the product appears dry following hydration and no connected mass has formed, additional liquid can be added dropwise and mixed with the product until the desired texture is obtained. If it is not possible to measure the volume for hydration add liquid carefully dropwise.

Application

For optimal adaptation of cerabone® plus to the bone and stability at the augmentation area, excess liquid should be removed from the defect site prior to the application. Intra-operatively, cerabone® plus performs optimally when bleeding at the defect site can be controlled, as in the case of well visible defects, e.g. in lateral augmentation.

Mixing with autologous bone

When working with autologous bone, the bone chips should be added to cerabone® plus prior to hydration. The required amount of liquid may differ from the hydration protocol and should be determined by careful dropwise addition of the liquid.

Fixation

Thorough fixation with a barrier membrane supports the stabilization of the bone grafting material at the application site. Moreover, in order to prevent ingrowth of soft tissue and to allow for undisturbed healing, the augmentation area should be covered with a barrier membrane according to the principles of GBR.

Osteoconductivity and volume stability of cerabone®plus proven properties of hyaluronate

  • Sticky and malleable following hydration
  • Efficient defect filling and time-saving application
  • Easy defect contouring
  • Minimized displacement of single granules during application

Product Specifications

Art.-No. cerabone Partice Size Content
1810 0.5 – 1.0 mm 1 x 0.5 ml
1811 0.5 – 1.0 mm 1 x 1.0 ml
1820 1.0 – 2.0 mm 1 x 0.5 ml
1821 1.0 – 2.0 mm 1 x 1.0 ml

Distribution

With our international network of distribution partners, we are near you in over 100 countries worldwide. In addition to our 360° productportfolio, we offer service, scientific advice and exchange, training and events directly on site from a single source.

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SPECIFIC FACTS

cerabone® plus is the only available bovine bone substitute material containing hyaluronate. It is a combination of cerabone® granules (available with small or large granules) and sodium hyaluronate, which is a water-soluble form of hyaluronic acid. The cerabone® granules are delivered with hyaluronate in a blister for convenient hydration.

Hyaluronic acid is a large organic polymer (polysaccharide) widely distributed throughout the human body as one major component of the extracellular matrix of many tissues such as skin, muscles, tendon, periodontal soft tissues and alveolar bone. Hyaluronic acid has structural and space-occupying functions and plays a major role in the body’s tissue repair processes1,2.

For the production of the recombinant sodium hyaluronate used in cerabone® plus state-of-the-art biotechnological fermentation processes are employed.

Due to its polymeric structure with many exposed reactive hydroxyl groups, hyaluronic acid forms covalent hydrogen bonds with water molecules in aqueous solutions. This way hyaluronic acid is able to retain huge amounts of liquids to form a hydrogel with high viscosity. It is estimated that the molecule can incorporate a volume of liquid that is 1000 times larger than the molecule itself.

cerabone® plus possesses all properties of the cerabone® granules, which are maximum safety (due to unique 1200°C manufacturing process), exceptional purity (100% pure bone mineral), human-like bone structure (rough surface, interconnected porosity) and long-term volume stability.

The cerabone® granules in cerabone® plus provide an osteoconductive scaffold for bone forming cells promoting osseous regeneration. As the cerabone® granules are only superficially resorbed, they provide long-term volume stability of the grafted site. The hyaluronic acid in cerabone® plus is completely resorbed by enzymatic degradation within the first weeks following implantation3.

Guide Bone substitute materials

Which product is most suitable for your indication, what are the alternatives and what do you have to pay particular attention to when using it? Our experts have compiled the most important information for you.

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botiss biomaterials GmbH

Hauptstrasse 28
15806 Zossen / Germany
Tel.: +49 33769 / 88 41 985
Fax: +49 33769 / 88 41 986
  1. Kyyak S, Blatt S, Wiesmann N, Smeets R, Kaemmerer PW. Hyaluronic Acid with Bone Substitutes Enhance Angiogenesis In Vivo. Materials (Basel). 2022 May 27;15(11):3839. doi: 10.3390/ma15113839. PMID: 35683136; PMCID: PMC9181602.
  2. Kyyak S, Pabst A, Heimes D, Kämmerer PW. The Influence of Hyaluronic Acid Biofunctionalization of a Bovine Bone Substitute on Osteoblast Activity In Vitro. Materials (Basel). 2021 May 27;14(11):2885. doi: 10.3390/ma14112885. PMID: 34072146; PMCID: PMC8198444.
  3. Pröhl A, Batinic M, Alkildani S, Hahn M, Radenkovic M, Najman S, Jung O, Barbeck M. In Vivo Analysis of the Biocompatibility and Bone Healing Capacity of a Novel Bone Grafting Material Combined with Hyaluronic Acid. Int J Mol Sci. 2021 May 1;22(9):4818.