maxgraft® granules are allograft bone substitute from human donor bone, processed by the Cells+Tissuebank Austria with a special cleaning process (Allotec® process) and available in cancellous and cortico-cancellous form. Due to its preserved natural bone structure and collagen content, it serves as a scaffold for natural bone regeneration and has the potential of complete remodeling into patients’ own bone 1,2.
The cancellous structure allows an optimal revascularization and supply of vital cells and therefore enables a rapid regeneration of vital bone tissue1. By adding a compact and dense bone ratio to the cancellous granules (maxgraft® cortico-cancellous granules) a greater volume stability is given, which is useful in cases of for example off-contour augmentations. Depending on the defect size, maxgraft® granules will be stably incorporated within 3–4 months and enable therefore an earlier re-entry in comparison to other grafting materials 2.
HIGH PATIENT ACCEPTANCE – SHORTER TREATMENT TIMES
Due to its high biological regenerative capacity and complete remodeling, maxgraft® represents an alternative to the patient’s own bone. The need for a second surgical site is eliminated, surgical time is shortened, and postoperative pain and morbidity for the patient are significantly reduced.
The processing of maxgraft® products preserves the natural collagen content and a residual moisture of <10%. Thus, a rehydration is not mandatory. However, rehydration in blood or saline solution can facilitate the handling and the insertion of maxgraft® granules due to better sticking together.
Compression of the particles should be avoided. Looser particles provide more space for blood vessel ingrowth and new bone formation.
Mixing with autologous bone
Mixing maxgraft® granules with autologous bone increases biological activity in the defect site and contributes to a more rapid regeneration and new bone formation.
Mixing with cerabone®
Mixing of maxgraft® granules with cerabone® combines the advantages of both materials. The biological potential of maxgraft® and the long-term volume stability of cerabone® lead to fast regeneration of strong vital bone.
Guided Bone Regeneration – Use of a barrier membrane
maxgraft® granules should be covered with a barrier membrane (e.g. Jason® membrane, collprotect® membrane) for the purpose of controlled bone regeneration; this prevents premature resorption and ingrowth of soft tissue.
Consideration of the soft tissue situation prior to surgery is necessary. The wound must be closed tension-free and saliva-proof. Overlapping mobilization of the soft tissue before suturing should be possible.
Depending on the defect morphology, the healing time of maxgraft® granules is 3-4 months (e.g. socket preservation, smaller bone defects, periodontal defects). Following healing, reentry with implant placement should be performed promptly to prevent degradation.
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maxgraft® granules are available in the form of both pure cancellous and cortico-cancellous granules. For the regeneration of bone defects, the cancellous structure enables rapid formation of new vital bone tissue, whereas the cortico-cancellous granules provide a higher volume stability. Greater volume stability is advantageous, for example, in augmentations outside the alveolar ridge contour. Depending on the defect size, maxgraft® granules are stably incorporated and partially remodeled within 3-4 months, thus enabling earlier re-entry compared to other bone graft substitutes 2.
maxgraft® is processed bone substitute material from human donors. All granules originate from femoral heads of living donors donated during hip arthroplasty surgery. Tissue procurement is standardized according to a predefined protocol and is performed by certified procurement centers. All tissue donations are made only after the donor has given written consent. In addition, the health status of the potential donor is assessed in advance as part of a risk analysis and the donor is then selected on the basis of strict exclusion criteria.
After a thorough analysis of the donors’ medical history, the high safety of maxgraft® is ensured by a series of stringent serological tests in combination with C+TBA’sAllotec® purification process and final radiological sterilization.
C+TBA is certified as a tissue procurement facility and tissue bank according to §19 and §22 of the Austrian Tissue Safety Act.
Guide Bone substitute materials
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