Comparative review demonstrates distinct material properties and bone healing patterns of cerabone® and Bio-Oss®

Main findings:

  • cerabone® and Bio-Oss® display distinctive physicochemical properties due to a different manufacturing process, in particular differences in the heat treatment
  • the different material properties directly affect the cellular response and healing of the two bone grafting materials
  • a higher number of multinucleated giant cells (MNGCs) was found after implantation of cerabone®, however ongoing research indicates that MNGCs are rather beneficial for the bone healing process on a long-term than a sign of a non-transient inflammatory state
  • cerabone® and Bio-Oss® demonstrated comparable bone formation rates as evidenced by preclinical and clinical data
  • numerous studies suggest only partial resorption of both bone grafts rather than complete remodeling, although there is limited evidence showing that cerabone is more stable


cerabone® and Bio-Oss®, although deriving from the same raw material, present with different materials characteristics, cellular responses and healing patterns. Bone formation rates of both bone grafts have demonstrated a comparable clinical performance. However, long-term studies suggest a higher stability of cerabone.