Nonincised Papillae Surgical Approach (NIPSA) in Periodontal Regeneration: Preliminary Results of a Case Series.
Moreno Rodriguez JA, Caffesse RG. Int J Periodontics Restorative Dent. 2018;38(Suppl):s105-s111.
https://www.ncbi.nlm.nih.gov/pubmed/30118534

This case series aims to clinically evaluate a new surgical approach to treat periodontal intrabony defects in conjunction with cerabone® and Emdogain®. Surgically, the defects are accessed via the alveolar mucosa preserving the interdental tissues (Nonincised Papillae Surgical Approach, NIPSA).

Methods:
Ten patients diagnosed with periodontal intrabony defects with a mean probing pocket depth (PPD) of 9.6 ± 2.3 mm were treated with the Nonincised Surgical Approach (NIPSA) in conjunction with cerabone® and Emdogain®. PPD reduction, clinical attachment level gain (CAL), keratinized tissue width and recessions were recorded six to 18 months post-surgery.

Results:
Healing was uneventful in all cases. PPD decreased to 2.3 ± 0.5 mm and a CAL gain of 7.3 ± 2.4 mm was found. Gingival papilla height, keratinized tissue width and buccal gingival margin remained stable over time. All defects presented negative bleeding on probing.

Conclusions:
Deep isolated intrabony defects can be successfully treated using the Nonincised Surgical Approach (NIPSA) in conjunction with cerabone® and Emdogain®. NIPSA preserves the interdental papillae and marginal keratinized tissues avoiding post-operative soft tissue shrinkage.

J. A. Moreno Rodriguez, Raul Caffesse