Platelet Rich Fibrin (PRF) is autologous biomaterial which is the second-generation platelet concentrate.

It has a favorable biological properties that accelerate healing of soft tissue and bone, causing a wide range of applications found in oral and maxillofacial surgery and other surgical fields.

In contrast to the PRP, the PRF is composed of autologous fibrin matrix in which are embedded a large amount of platelets and their growth factors, with prolonged time of releasing to seven days.

PRF-graft is used in augmentative techniques residual bone defects, alone or in combination with biomaterials. When the alveolar ridge augmentation technique GBR, the PRF membranes can be used for protection and stabilization of bone graft. PRF accelerates the healing of soft tissue and reduces the possibility of dehiscence and exposure of the membrane.