Scientific evidence for the combined use of mucoderm® and Emdogain® (3 Studies)

Healing of localized gingival recessions treated with a coronally advanced flap alone or combined with an enamel matrix derivative and a porcine acellular dermal matrix: a preclinical study.
Shirakata et al. Clin Oral Investig. 2016 Sep;20(7):1791-800.

Principal finding:
The combined use of mucoderm® and Emdogain® in coronally advanced flap procedures may promote periodontal regeneration in gingival recession defects.

Collagen Membranes Adsorb the Transforming Growth Factor-β Receptor I Kinase-Dependent Activity of Enamel Matrix Derivative.
Stähli et al. J Periodontol. 2016 May;87(5):583-90.

Principal finding:
mucoderm® has the ability to adsorb the TGF-β activity intrinsic to Emdogain® and makes it available for oral fibroblasts.

Biofunctionalization of porcine-derived collagen matrix using enamel matrix derivative and platelet-rich fibrin: influence on mature endothelial cell characteristics in vitro.
Park et al. Clin Oral Investig. 2017 Jul 11.

Principal finding:
Endothelial cell characteristics were overall improved by Emdogain®- or PRF- modified mucoderm®. Modification of mucoderm® with Emdogain or PRF may be a useful approach to improve clinical outcomes, to prevent inflammatory reactions and wound-healing disturbances.

J. S. Park, Y. Shirakata, Alexandra Staehli