Study about a novel liquid carrier system for enamel matrix proteins in combination with collacone®

A new study about a novel liquid carrier system for enamel matrix proteins in combination with collacone® has recently been published:

Miron RJ, Fujioka-Kobayashi M, Zhang Y, Sculean A, Pippenger B, Shirakata Y, Kandalam U, Hernandez M. Osteogain® loaded onto an absorbable collagen sponge induces attachment and osteoblast differentiation of ST2 cells in vitro. Clin Oral Investig. 2016 Dec 1. [Epub ahead of print]


The goal of this study was to determine the potential of Osteogain®, a liquid carrier for enamel matrix derivative, in combination with collacone® as a regenerative therapy for extraction socket management. The collacone® sponge was loaded with Osteogain® and the protein resorption and release as well as osteoblast binding and differentiation were investigated.


The proteins in Osteogain® were efficiently absorbed by collacone® and gradually released after a 10-day time period. Osteogain® induced a 50% increase in cell adhesion to collacone® and significantly stimulated cell differentiation as evidenced by the upregulation of osteoblast differentiation markers.

Conclusions and clinical relevance:

The combination of collacone® and Osteogain® offers a potential regenerative approach in extraction sockets to lower dimensional changes of the alveolar ridge. Osteogain® as a new formulation of the clinically utilized enamel matrix derivative (Straumann® Emdogain®) allows an efficient coating and retention of the proteins, thus an efficient delivery of the bioactive components to the site of action. At the same time, collacone®, which was designed for the use in extraction sockets, serves as an appropriate matrix for protein absorption. In vivo studies are currently underway to prove the combination approach.

Richard J. Miron, Masako Fujioka-Kobayashi, Y. Zang, Anton Sculean

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