https://www.sgo-iasgo.com/article/use-of-collagen,-ptfe-and-prf-membranes-in-bone-reconstruction-an-experimental-and-histomorphometric-study

Neculae I.I et al. 2017. J. Transl. Med. Res;22(1):42- 47.

Aim: 
Comparison of bone regeneration in standardized bone defects covered with membranes in an experimental animal model.
Material/Methods: 
In the left tibial bone of 18 rabbits, two defects/animal were created: one standardized 4 mm defect and a second by creating 5 monocortical holes with a small round bur. The defects were augmented with bovine bone, beta-tricalcium phosphate and perioglass and covered with a membrane: collagen (A), PTFE membrane (B) and PRF membrane (C). After 6 months results were analysed histomorphometrically.
Results/Conclusion: 
New regenerated bone covered by the collagen membrane (collprotect® membrane) presented a thickness of 98.26 μm followed by 49.19 μm for PTFE membrane, and 63.98 μm for PRF membrane. The density of osteoblasts and osteocytes had an average of 0.0012 for collagen membrane, 0.0009 for PTFE membrane and only 0.0010 for PRF membrane.
It can be concluded that bone regeneration differs depending on the type of barrier membranes used. There is an advantage of collagen membranes (collprotect® membrane) compared to non-resorbable d-PTFE membranes. Coverage of bone defects with barrier membranes create a favourable environment for bone regeneration.

I. Neculae