Vitamin D plays a major role in maintaining calcium balance and bone remodeling 1,2.
On the one hand, the vitamin D signaling pathway regulates calcium absorption via the intestine and thus contributes to an adequate calcium supply. On the other hand, vitamin D is also involved in the dynamic bone remodeling and mineralization processes 1. The signaling pathways triggered by vitamin D and the vitamin D receptor influence many important metabolic processes in the body 1. These include signaling pathways regulating growth hormones such as transforming growth factor β (TGFβ), epidermal growth factor (EGF), insulin growth factor 1 (IGF-1), hepatocyte growth factor (HGF) and bone morphogenetic proteins (BMP) 1. Vitamin D is therefore a relevant building block for healthy bone growth and its maintenance .
- Khammissa, R. A. G. et al. The Biological Activities of Vitamin D and Its Receptor in Relation to Calcium and Bone Homeostasis, Cancer, Immune and Cardiovascular Systems, Skin Biology, and Oral Health. Biomed Res Int 2018, 1–9 (2018).
- Liao, D. & Chen, C. Impact of Vitamin D Deficiency on Oral Health. International Journal of Integrated Medical Research 10, 22–26 (2023).