Buccal fat pad-derived stem cells with anorganic bovine bone mineral scaffold for augmentation of atrophic posterior mandible: An exploratory prospective clinical study.
Khojasteh A, Hosseinpour S, Rezai Rad M, Alikhasi M, Zadeh HH. Clin Implant Dent Relat Res. 2019 Apr;21(2):292-300.

This study aims to evaluate the efficacy of buccal fat pad-derived stem cells (BFPSCs) mixed with cerabone® in comparison to autologous bone for vertical and horizontal augmentation of the posterior mandible.

14 patients with horizontal and vertical alveolar ridge deficiencies of less than 4 and 8 mm respectively were treated with cerabone® either preloaded with BFPSCs (group 1) or mixed with autologous bone chips (group 2). A titanium mesh was used to cover the grafts and to stabilize the augmented sites. The surface areas of newly formed bone were determined by quantitative CBCT analysis. Images were taken pre-operative and six months post-surgery.


  • Total areas of newly formed bone were 5 ± 5.90 (group 1) and 166.75 ± 10.05 mm2 (group 2)
  • Areas of new bone formation for vertical defects were 164.91 ± 3.74 (group 1) and 169.36 ± 12.09 mm2 (group 1)
  • The area of new bone formation for horizontal deficiencies were 170.51 ± 4.54 mm2 (group 1) and 166.98 ± 9.36 mm2 (group 2)
  • Differences between the two groups were not statistically significant

The authors concluded that BFPSCs may be an alternative to autologous bone in alveolar ridge reconstruction as no differences in bone volume formation between the groups were found.