https://pubmed.ncbi.nlm.nih.gov/32680808/
Papi P, Pranno N, Di Murro B, Pompa G.  – Int J Oral Maxillofac Surg; S0901-5027(20)30248-4.

Aim:
The study evaluated the 2-year follow-up results of early implant placement with simultaneous peri-implant augmentation using mucoderm® and maxresorb® in the aesthetic zone.

Material/Methods:
Twenty patients were enrolled in this study and each patient was treated with one implant. Simultaneous contour augmentation with guided bone regeneration was performed using synthetic bone particles (maxresorb®) and an ADM (mucoderm®). Keratinized mucosa width (KMW) and gingival thickness (GT) were assessed at baseline, 1, 3, 6, 12, and 24 months. Marginal bone loss, probing pocket depth, bleeding on probing and plaque index were also recorded.

Results/ Conclusion:
GT and KMW increased between baseline and 1 month, slightly decreased between 1 month and 12 months, and remained significantly stable between 12 and 24 months. After 2 years, mean marginal bone loss level was 0.51 – 0.63 mm, with no probing pocket depth values >5 mm and no concomitant signs of inflammation registered. Pink aesthetic score was 8.3. Combining mucoderm® and maxresorb® for guided bone regeneration with early implant placement, revealed a significant increase of 1.9 mm for GT and 1.6 mm for KMW after 2 years. Patients were satisfied with the aesthetic outcome of the soft tissues as well as the prosthetic restoration.