Optimizes the basis for
improved oral health

botissCARE products stand for innovative point-of-care solutions for in vitro diagnostics that can be implemented directly in practice, as well as relevant measures for optimising factors that are necessary for maintaining the health of oral soft and hard tissues.


With the botissCARE quantitative vitamin D test, we offer you a quick point-of-care solution that lets you assess one of the most important health parameters for successful dental treatment in a chairside manner. This enables faster clinical decision-making and treatment planning than complicated laboratory tests. With the botissCARE quantitative vitamin D test, you expand your status as a point-of-care provider and trusted advisor for your patients.

*At the present time, we ship these products exclusively to dentists with practices in Germany. We will be happy to inform you when further countries are added. To stay up to date, please register here for our newsletter.

What Research says


discover at the heart of biomaterials

Trainingevent in Berlin

From September 2023 every 1st Wednesday of the month
from 4 – 6.30 p.m. | 3 CME points
botiss lectureroom | Ullsteinstr. 108, 12109 Berlin-Tempelhof

botissCARE Cubereader

The botissCARE CubeReader is an in vitro diagnostic device that reads and quantifies the results of a botissCARE Rapi-D Test™.

botissCARE Rapi-D

botissCARE Rapi-D™ Quantitative Vitamin D Test is an immunochromatography-based one step in vitro diagnostic test.


A Comfortable solution

To prevent vitamin D deficiency we recommend supplementing vitamin D3+K2 in the form of our spray – easy to take, effeciently absorbed and scientifically tested.

„We are not just mechanics, we are doctors of the oral cavity. And as such, if we’re going to do complex surgery, let’s measure vitamin D, let’s supplement, and let’s just add that extra measure to our patients, that allows us to not just be dentists, but to heal.“ Dr. Miguel Stanley


The success of your treatments can depend on your patients vitamin D levels. Vitamin D is known to contribute to the maintenance of normal bones, teeth and normal muscle function.³


Both caries and periodontal disease are associated with vitamin D deficiency and its pathophysiological processes, and with reduced mineralisation of the jawbone4, 5, 6, 7 resulting in increased susceptibility to bone loss, which can lead to complications in oral procedures, including implants.

Only 15 Minutes

The test system, consisting of a chairside rapid test and a digital reader, gives you an insight into your patients‘ vitamin D levels even before the first examination and thus a recommendation for the further procedure for the planned dental intervention.

  • A reliable result as a digital measured value in only 15 minutes
  • Test results comparable with laboratory results according to existing standard
  • Performed by dental professionals directly in the practice or clinic9, 10


* In case of vitamin D levels below than 12 ng/ml, please consult a general physician for a proper vitamin D therapy.

Overview of vitamin D-status derived from the various recommendations. (From consilium theme booklet vitamin D)8


With our international network of distribution partners, we are near you in over 100 countries worldwide. In addition to our 360° productportfolio, we offer service, scientific advice and exchange, training and events directly on site from a single source.

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Product Management

Any comments or questions?

Don’t hesitate to get in touch with us!

botiss biomaterials GmbH

Hauptstrasse 28
15806 Zossen / Germany
Tel.: +49 33769 / 88 41 985
Fax: +49 33769 / 88 41 986
  1. According to Implementing Regulation (EU) No. 828/2014

  2. According to EU Regulation 1169/2011

  3. European Food Safety Authority EFSA Panel Scientific Opinion on the substantiation of health claims related to vitamin D and maintenanceof bone and teeth (ID 150, 151, 158) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 2009; 7(9):1227.
  4. Hujoel PP. Vitamin D and dental caries in controlled clinical trials: systematic review and meta-analysis. Nutr Rev. 2013 Feb;71(2):88-97. doi: 10.1111/j.1753-4887.2012.00544.x. Epub 2012 Nov 9. PMID: 23356636.
  5. Dietrich T, Joshipura KJ, Dawson-Hughes B, Bischoff-Ferrari HA. Association between serum concentrations of 25-hydroxyvitamin D3 and periodontal disease in the US population. Am J Clin Nutr. 2004 Jul;80(1):108-13. doi: 10.1093/ajcn/80.1.108. PMID: 15213036.
  6. Scardina GA, Messina P. Good oral health and diet. J Biomed Biotechnol. 2012;2012:720692. doi: 10.1155/2012/720692. Epub 2012 Jan 26. PMID: 22363174; PMCID: PMC3272860.
  7. Schroth RJ, Levi JA, Sellers EA, Friel J, Kliewer E, Moffatt ME. Vitamin D status of children with severe early childhood caries: a case-control study. BMC Pediatr. 2013 Oct 25;13:174. doi: 10.1186/1471-2431-13-174. PMID: 24160554; PMCID: PMC4231606.
  8. National Institute of Health, USA
  9. Holick, MF. Vitamin D statues: Measurement, Interpretation and clinical application. Ann. Epidemiol. 2009, 19(2):73-78.
  10. Zerwekh JE. Blood biomarkers of vitamin D status. Am J. ClinNutr. 2008, 87:1087S-91S.