cerabone®

100% PURE BONE MINERAL

ULTIMATE VOLUME STABILITY

SUPERIOR HYDROPHILICITY

CE MARKING SINCE 2002

cerabone® is a 100% pure bone mineral of bovine origin manufactured by a unique 1200°C production process. It has been successfully applied in millions of patients in regenerative dentistry and has been in use for more than 20 years in various medical applications (e.g. craniofacial surgery, oncology and hand and spine surgery).

MAXIMUM SAFETY

The sophisticated processing of the bovine bone removes all organic components resulting in a bone mineral with exceptional purity1. In addition, potential infectious agents such as bacteria, viruses and prions are removed through the high temperature treatment 2. Both product and production process are fulfilling applicable national and international regulatory and safety requirements for bovine bone grafts including ISO 22422-1, ISO 22442-2 and ISO 22442-3.

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Generally, the high stability of cerabone® makes it the ideal choice in cases where long-term stability is important.

IMPLANTOLOGY, PERIODONTOLOGY AND ORAL AND CMF SURGERY

  • Sinus lift
  • Horizontal and vertical augmentation
  • Ridge preservation
  • Peri-implant defects
  • Socket preservation
  • Bone defect augmentation
  • Periodontal intrabony defects
  • Furcation defects (class I and II)
Choice of particle size

Small cerabone® particles (0.5 – 1.0 mm) allow good adaptation to surface contours; they are especially useful for lateral augmentations or to fill voids when working with autologous bone blocks. For sinus lift and extensive augmentations the use of large cerabone® particles (1.0 – 2.0 mm) is recommended. The increased space between the large particles enables a better vascularization and improves the regeneration of larger defect

Hydration

cerabone® granules can be applied dry or wet. Hydration in blood or sterile saline solution facilitate the handling and application of the granules, as they adhere to each other

Compacting of the granules

To provide space for the regenerative process only gentle compression of the granules is recommended. It allows for revascularization and osseointegration of the bone grafting particles by the three-dimensional pore network of cerabone®.

Stabilization of the granules

The cerabone® granules should always be covered by a membrane in order to immobilize the particles at the augmented site and to prevent soft tissue ingrowth into the bone defect. When treating defects outside the ridge contour, a fixation of the membrane by pins or screws can be advantageous.

Healing time and re-entry

A healing time of at least 6 months is recommended before re-entry to ensure stable integration of the particles.

Mixing with autograft

Mixing of cerabone® with autologous bone adds a biological activity (osteoinductive and osteogenetic properties of autologous bone) and supports faster regeneration and improved formation of new bone.

Mixing with allograft (maxgraft®)

Mixing of cerabone® with allogeneic bone (maxgraft®) combines the advantages of both materials; the biological potential of maxgraft® and the long-term stability of cerabone® lead to fast regeneration of vital, strong bone.

  • 100% pure natural bone mineral
  • Human-like bone structure
  • Rough, hydrophilic surface
  • Ultimate volume stability
  • Easy handling

Product Specifications

Art.-No. Particle Size Content
1510 0.5 – 1.0 mm 1 × 0.5 ml
1511 0.5 – 1.0 mm 1 × 1.0 ml
1512 0.5 – 1.0 mm 1 × 2.0 ml
1515 0.5 – 1.0 mm 1 × 5.0 ml
1520 1.0 – 2.0 mm 1 × 0.5 ml
1521 1.0 – 2.0 mm 1 × 1.0 ml
1522 1.0 – 2.0 mm 1 × 2.0 ml
1525 1.0 – 2.0 mm 1 × 5.0 ml

Distribution

With our international network of distribution partners, we are near you in over 100 countries worldwide. In addition to our 360° productportfolio, we offer service, scientific advice and exchange, training and events directly on site from a single source.

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SPECIFIC FACTS

cerabone® is a bone mineral of exceptional purity and high crystallinity – as opposed to non-sintered bone grafts, no remnants of water or calcium carbonate are found1.

Potential infectious agents such as bacteria, viruses and prions are removed through the high temperature treatment. Heating above 800°C ensures a complete inactivation of the infectivity of potential prions2.

cerabone® shows excellent mechanical and biological stability as pure bone apatite is virtually insoluble – this is the reason for cerabone®’s ultimate volume stability. Permanent structural support of the augmented site will be provided.

cerabone® by its unique material properties provides a cell-friendly environment thus efficiently supporting the osseous regenerative process. cerabone® is a highly porous bone grafting material with a porosity of ~65-80% and a mean pore size of ~600-900 μm.

Guide Bone substitute materials

Which product is most suitable for your indication, what are the alternatives and what do you have to pay particular attention to when using it? Our experts have compiled the most important information for you.

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botiss biomaterials GmbH

Hauptstrasse 28
15806 Zossen / Germany
Tel.: +49 33769 / 88 41 985
Fax: +49 33769 / 88 41 986
  1. Tadic, D. and Epple, M. (2004), “A thorough physicochemical characterisation of 14 calcium phosphate-based bone substitution materials in comparison to natural bone”, Biomaterials, Vol. 25 No. 6, pp. 987–994
  2. Brown, P., Rau, E.H., Johnson, B.K., Bacote, A.E., Gibbs, C.J. and Gajdusek, D.C. (2000), New studies on the heat resistance of hamster-adapted scrapie agent: threshold survival after ashing at 600 degrees C suggests an inorganic template of replication, PNAS, Vol. 97 No. 7, pp. 3418–3421.
  3. Seidel P, Dingeldein E. cerabone® – Bovine Based Spongiosa Ceramic Seidel et al. Mat.-wiss. u. Werkstofftech. 200
  4. Trajkovski et al. 2018. Hydrophilicity, Viscoelastic, and Physicochemical Properties Variations in Dental Bone Grafting Substitutes. Materials (Basel). 30;11(2). pii: E215.